Infants with spinal muscular atrophy 1 (SMA1) experience severe weakness before 6 months of age. Muscle weakness, lack of motor development and poor muscle tone ( hypotonia) are the major features of SMA1.   Infants with the poorest outlook have problems with breathing and feeding (sucking and/or swallowing).
SMA Type 1 is the most severe form of SMA with symptoms usually beginning between 0 and 6 months. Generally speaking, the earlier the onset of symptoms the more severe the condition. Babies are unable to sit without support and may be described as ‘non-sitters’.
Type 1, also called infantile-onset SMA or Werdnig-Hoffmann disease, is the most common type of SMA, accounting for 60% of cases. Symptoms usually begin in the first six months of life, and typically include muscle weakness, poor muscle tone, developmental delays, and difficulties breathing and swallowing.
Type 1 is the most common and severe form of SMA. It’s sometimes called Werdnig-Hoffmann disease or infantile-onset SMA. Children with type 1 have limited movement, can’t sit without support, and have trouble breathing, feeding, and swallowing. Symptoms begin at birth or within the first six months of life.
Spinal Muscular Atrophy (SMA) type 1, also known as Werdnig-Hoffmann disease, is the most common diagnosed form of SMA, accounting for approximately half of all patients with SMA. 1 SMA type 1 is a degenerative neuromuscular condition and without life-prolonging interventions such as mechanical ventilation, this form of SMA is nearly.
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