The frequency and severity of systemic adverse events was higher after dose 2 than dose 1. Fatigue, headache, chills, and new or worsened muscle pain were most common. The majority of systemic events were mild or moderate in severity, after both doses. Fever was more common after the second dose than after the first dose.
But the second dose of both vaccines has quickly gained a reputation for packing a punch, with side effects that may include fatigue, chills, headache, muscle aches and pains, and even a fever. “More people — 40 to 50 percent — experience some of these symptoms to one degree or another after the second vaccine,” Schaffner says.
These findings closely mirror the side effect data collected from Pfizer’s second vaccine shot. Other side effects recorded in the booster trial also fall in line with symptoms documented after the primary Pfizer series. They include muscle and joint pain, chills, diarrhea, vomiting and fever.
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