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In 1986, MDA-supported researchers identified a gene on the X chromosome that, when flawed mutated , causes Duchenne, , and an intermediate form of muscular dystrophies.




MDA Dicamba misuse investigations find common label violations





MDA Dicamba misuse investigations find common label violations





Causes/Inheritance



Causes/Inheritance



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Each son born to a woman with a dystrophin mutation on one of her two X chromosomes has a 50 percent chance of inheriting the flawed gene and having DMD.

In addition to its force-transfer role, dystrophin provides the scaffold for holding numerous molecules in place near the cell membrane.



This article was submitted by the Minnesota Department of Agriculture.









Because it connects the center of the muscle cell to the edge of the cell, the dystrophin protein is extremely long.




Description: Many cases of DMD are caused by mutations in the part of the gene that encodes this middle section.

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The dystrophin protein transfers the force of muscle contraction from the inside of the muscle cell outward to the cell membrane.
The repeated spectrin units in the middle of the protein play an important role in linking the two ends, but studies have shown that the exact number of these units is not critical for the function of the protein as a whole.
Early in the embryonic development of a female, either the X chromosome from the mother maternal X or the one from the father paternal X is inactivated in each cell.

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