Colchicine is a unique, sophisticated anti-inflammatory agent that has been used for decades for the prevention of acute inflammatory flares in gout and familial Mediterranean fever. In recent years, clinical trials have demonstrated its potential in a range of cardiovascular (CV) conditions. Colchi …
In the majority of cases, the doses of colchicine were within the therapeutic range. An algorithm for dosage adjustments of colchicine during concomitant treatment with multiple CYP3A4/P-gp inhibitors to improve safety have been proposed based on an in vivo single dose pharmacokinetic study . P-gp is encoded by the multidrug resistance gene-1.
You can take your Colchicine tablets with or without food, it doesn’t matter either way. How to take Colchicine for a gout attack – for gout attacks, you’d normally take one tablet 2 to 4 times a day until your symptoms are all gone. You shouldn’t take more than 12 tablets for 1 gout attack.
Dosage for Colchicine To treat acute gouty arthritis the usual dose of colchicine to relieve or abort an attack is 1 to 1.2 mg (two 0.5 mg granules or two 0.6 mg tablets). This dose may be followed by one unit of either preparation (granule or tablet) every hour, or two units every two hours, until pain is relieved or until diarrhea ensues.
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