Ivermectin coronavirus - Ivermectin: Uses, Dosage, Side Effects, Warnings
The ivermectin part of this trial started in June 2021 and results will be published when available.
PRINCIPLE TRIAL The PRINCIPLE trial is a current trial investigating treatments for COVID-19 patients in the community who are more at risk of serious illness.
In short, it is far too early to claim that ivermectin is an effective cure or a treatment, or that it may become one in the near future.
There is currently insufficient evidence from the COVID-19 Treatment Guidelines Panel to recommend either for or against the use of ivermectin in Covid-19 patients for the treatment of severe or mild COVID-19 symptoms.
The FDA first issued a warning in April 2020 that ivermectin intended for use in animals should not be used to treat COVID-19 in humans. This warning was updated and reiterated in 2021. Clinical Trials Several clinical trials evaluating the use of ivermectin for the treatment of COVID-19 are currently underway or in development.
Moderate-certainty evidence finds that large reductions in COVID-19 deaths are possible using ivermectin. Using ivermectin early in the clinical course may reduce numbers progressing to severe disease. The apparent safety and low cost suggest that ivermectin is likely to have a significant impact on the SARS-CoV-2 pandemic globally.
The molecular hypothesis of ivermectin's antiviral mode of action suggests an inhibitory effect on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication in the early stages of infection. Currently, evidence on efficacy and safety of ivermectin for prevention of SARS-CoV-2 infection and COVID-19 treatment is conflicting.
In June 2020, ivermectin, a Food and Drug Administration (FDA)–approved antiparasitic drug, was shown to have antiviral effects against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro [ 1 ]. Following this, ~86 clinical trials investigating ivermectin for coronavirus disease 2019 (COVID-19) have been registered globally.
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